Alprostadil is also available as an intraurethral suppository. Comments: Maximum dose: 2 systems per 24-hour period Medically reviewed by Drugs.com. Doses greater than 40 mcg have not been studied. Alprostadil injection is injected into the side of the penis. The risks of long-term infusion of Alprostadil injection should be weighed against the possible benefits that critically ill infants may derive from its administration. As an adjunct to the diagnosis of erectile dysfunction, inject CAVERJECT intracavernosally and monitor patients for the occurrence of an erection. Doses greater than 60 mcg are not recommended. Comments: Use a new vial for each dose of CAVERJECT. -IV: Store in a refrigerator at 2 to 8C (36 to 46F). A. Several alprostadil products can be injected. When starting the treatment, your doctor will give you a small dose and then gradually increase the dose if necessary. Its solubility at 35°C is 8000 micrograms per 100 mL double distilled water. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Administration of the first injections of CAVERJECT should be done in the physician's office by medically trained personnel. Muse ; Canadian Brand Name. Generic name: ALPROSTADIL 20.5ug in 1mLDosage form: injection, powder, lyophilized, for solution. edex ® (alprostadil for injection) is available in single-dose, dual-chamber cartridges intended for use with the reusable edex ® injection device. The erection usually starts within 5-20 minutes after injection and the duration of erection is dose dependent. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The alprostadil is reconstituted with the sterile bacteriostatic water just before injection. Your exact dose will be determined by your doctor. Maintenance dose: 0.01 to 0.4 mcg/kg/min continuous IV infusion Used requires ventilatory assistance to be immediately available. The chemical name for alprostadil is (11α,13E,15S)-11,15 dihydroxy-9-oxo-prost-13-en-1-oic acid, and the molecular weight is 354.49. Initiate dosing with 2.5 mcg of alprostadil. Initiate dosing with 1.25 mcg of alprostadil. Refer to the Patient Information and Instructions for Use in the FDA-approved patient labeling for the complete detailed instructions on reconstitution and needle preparation steps. If additional titration is required, a dose of 5 mcg may be given during the next 24 hours. For Adult. Initially 250 micrograms, adjusted according to response; usual dose 0.125–1 mg; maximum 2 doses per day; maximum 7 doses per week. Find patient medical information for Alprostadil Injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It is used for the treatment of erection disorders and improving the blood flow in newborn babies having a birth defect of the heart. An erection should occur within 5 to 20 minutes and last up to 60 minutes. When the desired effect on the ductus arteriosus (a passageway in your baby's heart) is achieved, the infusion rate is usually decreased to the lowest possible dose while still maintaining the desired effect on the ductus arteriosus. Do not take a double dose of Alprostadil. With urethral use Manufacturer advises during initiation of treatment the urethral application should be used under medical supervision; self-administration may only be undertaken after proper training. An erection should occur within 5 to 20 minutes and last up to 60 minutes. i) Subjects without evidence of neurological dysfunction; 20 micrograms alprostadil to be injected into the corpus cavernosum and massaged through the penis. Alprostadil urethral suppository is used to treat men who have erectile dysfunction (also called sexual impotence). The site of injection is either the right or left lateral penis. Alprostadil Overview. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Available dosage form in the hospital: - ALPROSTADIL 20MCG AMP - ALPROSTADIL 20MCG INTRACAVERNOSAL VIAL Trade Names: Dosage: -Erectile dysfunction:-Intracavernous (Caverject®, Edex®): Individualize dose by careful titration; doses >40 mcg (Edex®) or >60 mcg (Caverject®) are not recommended: Initial dose must be titrated in physician's office. Alprostadil is an endogenous substance known as prostaglandin E 1 (PGE 1). Do not use the solution if it is cloudy, colored or contains particles. Alprostadil is administered by direct intracavernous injection. Measure improvement of systemic blood pressure and blood pH in patients with restricted systemic blood flow. These cases are fitted with a lock designed for safe and convenient disposal of the contents after use. CAVERJECT- alprostadil injection, powder, lyophilized, for solution ... 13, 14-dihydro-15-oxo-PGE 1, increased to reach a peak 30 minutes after injection and returned to pre-dose levels by 60 minutes after injection. Intracavernous and Transurethral: Individual dosages are determined by series of trial injections under physician supervision. Combination of the two drugs produced much high response: 100, 85.7 and 55.5% in arterial, neurogenic and vein occlusive ED, respectively. Advise the patient to read and carefully follow the. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Alprostadil comes as a cream, an injection, or in pellet form. Use the medicine exactly as directed. Follow all directions on your prescription label and read all medication guides. Less than 12 Months: Initial dose: 0.05 to 0.1 mcg/kg/min continuous IV infusion Maintenance dose: 0.01 to 0.4 mcg/kg/min continuous IV infusion Comments: -The preferred route is continuous IV infusion into a large vein; may also be administered through an umbilical artery catheter placed at the ductal opening. Drug information provided by: IBM Micromedex. All men were fully trained in the self-injection technique before entry into the home phase. Doses started with 2.5 micrograms, the … Extensions of this testing are the use of CAVERJECT as an adjunct to laboratory investigations, such as duplex or Doppler ultrasound imaging. If you use alprostadil (either by injection or suppository) and have sex with a pregnant woman, use a condom. Any alprostadil entering the systemic circulation from the corpus cavernosum will be rapidly metabolised. This open-label, dose-escalation study investigated the efficacy and safety of alprostadil (PGE1, prostaglandin E1) Sterile Powder (S.Po.) Use: Palliative, not definitive, therapy to temporarily maintain ductus arteriosus patency until corrective or palliative surgery can be performed in neonates with congenital heart defects who depend upon the patent ductus for survival. 21 to 27 gauge needle for reconstitution 4. When the cartridge is placed into the edex ® injection device and reconstituted, the deliverable amount of alprostadil in each milliliter is 10, 20, or 40 mcg, respectively. Initial 2.5 mcg intracavernosal injection; Titrate by 2.5 mcg, THEN by 5-10 mcg intervals until erection of ; 1 hr maintained; not to exceed 40 mcg (Edex) or 60 mcg (Caverject) If no absolute response to 2.5 mcg dose, may increase second dose to 7.5 mcg followed by increments of 5-10 mcg One chamber of the cartridge contains 10.75, 21.5, or 43 mcg of alprostadil as a white, sterile, lyophilized powder. It keeps the ductus arteriosus (a passageway in the heart) open until surgery can be done. Alprostadil injection is injected into the side of the penis. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Alprostadil injection dosage for intracavernous administration (in the treatment of Erectile dysfunction): (Note: Doses greater than 40 mcg (Edex®) or greater than 60 mcg (Caverject®) are not recommended) The patient may be given the first two doses in the physician’s office one hour apart. Apnea is experienced by about 10-12% of neonates with congenital heart defects treated with alprostadil injection. The recommended initial dosage of alprostadil is calculated by your doctor based on body weight. Alprostadil injection is injected into the side of the penis. Administration advice: Refer to manufacturer product information. Alprostadil relaxes the smooth muscles present in the wall of blood vessels and helps in increasing the flow of blood in certain specific areas of the body. By expanding blood stream to the penis, alprostadil assists speed up an erection. -Better responses to the IV formulation are obtained in patients with low oxygen partial pressures (less than 40 mmHg) than in patients with high oxygen partial pressures (greater than 40 mmHg). INTRACAVERNOUS: The maximum dose is 60mcg per day. Allow a 24 hour interval between doses. This medicine causes an erection because it … It is used to treat babies with certain types of congenital heart defects. Alpostin 5mcg - 1ml Injection (Alprostadil) drug information. -Transurethral: Store unopened foil pouches in a refrigerator at 2 to 8C (36 to 46F). (2) TRIMIX – a combination of alprostadil, phentolamine and papaverine is available in four different strengths. Do not use more than 2 pellets in one day. Less than 12 Months: Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. However, due to efficacy, cost, and side effects, it is not used often. Initial dose: 125 or 250 mcg inserted into the urethra Using the injection: The injection is given at the base of the penis. Alprostadil treatment acts directly on the penis as a cream, penile insertion or injection. -If response to initial dose is inadequate, dosage can be increased up to 0.4 mcg/kg/min. The risks of long-term infusion of alprostadil injection should be weighed against the possible benefits that critically ill infants may derive from its administration. This is meant to avoid the effects of having too much medication in your penis – while the majority of effects wear off quickly, it is possible for some dosage to linger. However, in general, higher infusion rates do not produce greater effects. Alprostadil is a white to off-white crystalline powder with a melting point between 110° and 116°C. Structural Formula The same effect can now be achieved by inserting this new formulation into the urethra. See. Replace the needle used for reconstitution with a 29 or 30 gauge one-half inch needle prior to injection. Syringe and Dose Injection Technique. The injections available through our laboratory include: (1) BIMIX – various combination of alprostadil and phentolamine are available. Alprostadil is used as needed before sexual activity. Following intracavernosal injection of 20 mcg alprostadil, peripheral levels of the major circulating metabolite, 13, 14-dihydro-15-oxo-PGE 1, increased to reach a peak 30 minutes after injection and returned to pre-dose levels by 60 minutes after injection. 2 kg at birth and usually appears during first hr of drug infusion Monitor respiratory status throughout treatment. However, due to efficacy, cost, and side effects, it is not used often. After intravenous administration of tritium-labeled alprostadil in man, labeled drug disappears rapidly from the blood in the first 10 minutes, and by 1 hour radioactivity in the blood reaches a low level. 500 micrograms for 1 dose. Maximum dose: 3 times per week, with at least 24 hours between each use The effective alprostadil dose, ie the dose producing penile rigidity adequate for intercourse and lasting up to 60 min, was established by titration at the clinic prior to entry into the 6 month self-treatment home phase. 29 or 30 gauge one-half inch needle for injection 5. alcohol swabs 1. Usual dose range: 5-20 mcg. CAVERJECT is available in single-dose vials containing 20 mcg or 40 mcg of alprostadil. Contraindications. Alprostadil was more effective in arterial and neurogenic ED (83.3 vs 66.7 and 78.6 vs 57.1%, respectively). Apnea is most often seen in neonates weighing . Adult: Initially, 2.5 mcg, followed by 5 mcg if there is partial response or 7.5 mcg if there is no response.Subsequent increments of 5-10 mcg are given until suitable dose is reached. Visually inspect the solution in the vial for particulate matter and discoloration. Consult WARNINGS section for additional precautions. Inject this medicine very slowly into your penis as shown to you by your doctor 10 to 30 minutes before intercourse. -The patient must remain in the physician's office following the first dose until complete detumescence occurs. Apnea is most often seen in neonates weighing . Alprostadil is also available as an intraurethral suppository. Grasp the head of the penis with the thumb and forefinger and stretch it length-wise along the thigh. edex ® (alprostadil for injection) is a sterile, pyrogen-free powder containing alprostadil in an alfadex (α-cyclodextrin) inclusion complex. 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